March 16th, 2021

Some Side Effects Are Not A Coincidence: mRNA COVID-19 Vaccines Cause Lymphadenopathy

INTRODUCTION
On February 28, 2021 a letter entitled "Urgent Open Letter from Doctors and Scientists to the European Medicines Agency regarding COVID-19 Vaccine Safety Concerns” was released.(1)  Calling themselves Doctors4covidethics, they expressed grave concerns about gene-based COVID-19 vaccines. They raise three different issues of principle:
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1. Many side effects of these vaccines have appeared in previously healthy young people.
2. There have been many reports of people in care homes being infected by Covid-19 after they have been vaccinated.
3. We have some doubt that key issues about the safely of these vaccines were adequately examined before their approval.

They also demanded that the European Medicines Agency provide additional evidence on seven different points. In conclusion they state that "the approval of the COVID-19 vaccines by the EMA was premature and reckless, and the administration of the vaccines constitutes 'human experimentation', which is in violation of the Nuremberg Code." Finally they demand "that approval for use of the gene-based vaccines be withdrawn until all the seven issues have been properly addressed by the exercise of due diligence by the EMA."
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In what follows, with the help of the doctors4covidethics and Wikipedia, I will show how one of the seven points raised in their letter can give us a cogent explanation of one of the common side effects listed in the UK’s Case Series Drug Analysis, Lymphadenopathy.(2) Once we understand how an mRNA vaccine works, and examine points 1. and 3. in their letter, it will be obvious that the observed cases of Lymphadenopathy are directly caused by the administration of an mRNA vaccine.
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HOW AN mRNA VACCINE WORKS
We must begin with a description of how an mRNA vaccine works. This account is taken from a website of the Center for Disease Control, the CDC.
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"COVID-19 mRNA vaccines give instructions for our cells to make a harmless piece of what is called the “spike protein.” The spike protein is found on the surface of the virus that causes COVID-19.
COVID-19 mRNA vaccines are given in the upper arm muscle. Once the instructions (mRNA) are inside the immune cells, the cells use them to make the protein piece. After the protein piece is made, the cell breaks down the instructions and gets rid of them.
"Next, the cell displays the protein piece on its surface. Our immune systems recognize that the protein doesn’t belong there and begin building an immune response and making antibodies, like what happens in natural infection against COVID-19.
"At the end of the process, our bodies have learned how to protect against future infection. The benefit of mRNA vaccines, like all vaccines, is those vaccinated gain this protection without ever having to risk the serious consequences of getting sick with COVID-19."(3)

IMAGE FROM WIKIPEDIA(4)
The “immune cells” in the description above are known as Dendritic cells. "Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system."(5) Other cells in the body "can potentially absorb vaccine mRNA, manufacture spikes, and display spikes on their surfaces, however dendritic cells absorb the mRNA globules much more avidly.(6)
"Once the viral antigens are produced by the host cell, the normal adaptive immune system processes are followed. Antigens are broken down by proteasomes, then class I and class II MHC molecules attach to the antigen and transport it to the cellular membrane, 'activating' the dendritic cell. Once the dendritic cells are activated, they migrate to lymph nodes, where the antigen is presented to T cells and B cells.This eventually leads to the production of antibodies that are specifically targeted to the antigen, resulting in immunity."(7)
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THE mRNA VACCINES CAUSES AN AUTOIMMUNE RESPONSE
This is the first comment on mRNA vaccines in the letter from the doctyors4covidethics:
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1. Following intramuscular injection, it must be expected that the gene-based vaccines will reach the bloodstream and disseminate throughout the body [1].
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In their second comment they discuss the effect this will have on endothelial cells, but this will be discussed in another article.This is the third comment:
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It must be expected that during expression of the vaccines’ nucleic acids, peptides derived from the spike protein will be presented via the MHC I — pathway at the luminal surface of the cells. Many healthy individuals have CD8-lymphocytes that recognize such peptides, which may be due to prior COVID infection, but also to cross-reactions with other types of Coronavirus.[3; 4] [5]. We must assume that these lymphocytes will mount an attack on the respective cells.
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In the account given by the CDC, the nanoparticles in the vaccine will enter and be processed by the dendritic cells. Then the “cell displays the protein piece [it has created from the nanoparticle] on its surface. Our immune systems recognize that the protein doesn’t belong there and begins building an immune response and making antibodies...” A passage from Wikipedia explains this process as follows: “Once the dendritic cells are activated, they migrate to lymph nodes, where the antigen is presented to T cells and B cells.”(8)
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But the doctors4covidethics explain that many people will have been exposed to COVID or other types of Coronavirus. This means that the “spike” protein (made up of long chains of amino acids) which occurs on all coronavirus or peptides (smaller chains of amino acids) which are parts of the spike protein, will be recognized as belonging to a pathogen. Thus when the dendritic cell displays “the protein piece” created from the vaccine’s nanoparticle the immune system will not “begin to build an immune response and make antibodies...” or just “migrate to the lymph nodes”. Instead, since the dendritic cell displays a protein piece created from the vaccine nanoparticle, it will be attacked by the CD8-lymphocytes that recognize such peptides as pathogens.
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We can see that in the story the CDC tells assumes nobody has been exposed to COVID or any other types of Coronavirus. They assume the immune system is ignorant of the threat of COVID, and the mRNA vaccine is going to teach the immune system to be prepared to attack it. But introducing the spike protein will not "teach" the immune system anything if a person has had some previous exposure to any type of Coronavirus. The cell which displays the recreated spike protein will be attacked because it has already been recognized as a pathogen and the immune system via the CD8-lymphocytes will destroy it.
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We should note that in the COVID-19 mRNA Pfizer- BioNTech vaccine analysis print of March 9th, 2021 from the UK’s Case Series Drug Analysis, there are 1973 reports of Lymphadenopathy and 266 reports of Lymph node pain.(9)
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Lymphadenopathy is considered to be a nonmalignant hyperimmune reaction to chronic antigenic stimuation; there is proliferation of B cells accompanied by profound deficiency of T cells.”(10)
Lymphadenopathy is a common and nonspecific sign. Common causes include infections (from minor ones such as the common cold to serious ones such as HIV/AIDS), autoimmune diseases, and cancers.” (11)
Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large amounts of antibodies.”(12)
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So what’s going on in the lymph nodes? There is a hyperimmune reaction to chronic antigenic stimuation, autoimmune activity, and the secretion of large amounts of antibodies. Isn’t this just what the doctors4covidethics describe in their third comment?
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In the COVID-19 mRNA Pfizer- BioNTech vaccine analysis print of March 9th, 2021 we can also find 437 cases of COVID-19 reported as a possible adverse event with 22 deaths from this infection and 415 cases of influenza. It has been suggested that the mRNA vaccines actually shut down the immune system and we have just seen how this can happen. Since the immune system is overloaded by an attack on the cells producing the viral particles, it is in efffect unable to deal with other pathogens which happen to be present. This might explain why a medication that is supposed to protect us from COVID-19 infection sometimes allows this infection or an influenza to take hold. In cases where the person has already been exposed to COVID-19 or another Coronavirus, the mRNA medication interferes with the normal action of the immune system so a person can no longer fight off other pathogens.
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Finally, if the doctors4covidethics are explaining that the immune system will attack the cells producing the viral particles. then they will attack the body's own cells, as in rheumatoid arthritis or any autoimmune disease. So the mRNA vaccines cause an autoimmune response under certain conditions which are by no means rare.
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Some might object that lymphadenopathy is not a serious problem for mRNA vaccines because it is "just" lymphadenopathy, which is transient. If this was the only problem, those who don't experience lymphadenopathy might be inclined to think it is of no imtportance. However this ignores the situation described by the doctors4covidethics in their first point.  The nanoporticles in the injection "disseminate throughout the body". In other words, for people who have been exposed to COVID-19 or any other type of Coronavirus, their immune system is already set to attack the activated dendritic cells showing the antigen derived from the nonoparticle. Since the nanoparticles are disseminated throughout the body, they will be attacked anywhere they can be found. The vaccine does not work to destroy any COVID-19 virus, it works to mobilize the immune system to attack the dendritic cells that are modified by the nanoparticles. And I have argued that this complete focus on the newly created dendritic cells means that the person can be infected by any other pathogen that happens to be present.
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FOOTNOTES FOR DOCTORS4COVIDETHICS LETTER
[1] Hassett, K. J.; Benenato, K. E.; Jacquinet, E.; Lee, A.; Woods, A.; Yuzhakov, O.; Himansu, S.; Deterling, J.; Geilich, B. M.; Ketova, T.; Mihai, C.; Lynn, A.; McFadyen, I.; Moore, M. J.; Senn, J. J.; Stanton, M. G.; Almarsson, Ö.; Ciaramella, G. and Brito, L. A.(2019).Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines, Molecular therapy. Nucleic acids 15 : 1–11.
[2] Chen, Y. Y.; Syed, A. M.; MacMillan, P.; Rocheleau, J. V. and Chan, W. C. W.(2020). Flow Rate Affects Nanoparticle Uptake into Endothelial Cells, Advanced materials 32 : 1906274.
[3] Grifoni, A.; Weiskopf, D.; Ramirez, S. I.; Mateus, J.; Dan, J. M.; Moderbacher, C. R.; Rawlings, S. A.; Sutherland, A.; Premkumar, L.; Jadi, R. S. and et al.(2020). Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals, Cell 181 : 1489–1501.e15.
[4] Nelde, A.; Bilich, T.; Heitmann, J. S.; Maringer, Y.; Salih, H. R.; Roerden, M.; Lübke, M.; Bauer, J.; Rieth, J.; Wacker, M.; Peter, A.; Hörber, S.; Traenkle, B.; Kaiser, P. D.; Rothbauer, U.; Becker, M.; Junker, D.; Krause, G.; Strengert, M.; Schneiderhan-Marra, N.; Templin, M. F.; Joos, T. O.; Kowalewski, D. J.; Stos-Zweifel, V.; Fehr, M.; Rabsteyn, A.; Mirakaj, V.; Karbach, J.; Jäger, E.; Graf, M.; Gruber, L.-C.; Rachfalski, D.; Preuß, B.; Hagelstein, I.; Märklin, M.; Bakchoul, T.; Gouttefangeas, C.; Kohlbacher, O.; Klein, R.; Stevanović, S.; Rammensee, H.-G. and Walz, J. S.(2020). SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition, Nature immunology.
[5] Sekine, T.; Perez-Potti, A.; Rivera-Ballesteros, O.; Strålin, K.; Gorin, J.-B.; Olsson, A.; Llewellyn-Lacey, S.; Kamal, H.; Bogdanovic, G.; Muschiol, S. and et al.(2020). Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19, Cell 183 : 158–168.e14.
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